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무료슬롯 프라그마틱 designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as recruitment and consent, adherence, and the use of commonly available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias is also essential. However too much heterogeneity could lead to issues with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they shouldn't be used as a substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.
There is a positive increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.